Brief information about it:
Letrozole is a medication used to stimulate ovulation in women with infertility. It works by blocking the production of estrogen, which can help stimulate the release of an egg from the ovary.
Uses:
· Infertility: Letrozole is often used as a first-line treatment for infertility caused by ovulation disorders.
· Polycystic ovary syndrome (PCOS): It can also be used to treat infertility in women with PCOS.
Mechanism of action:
Letrozole works by blocking the enzyme aromatase, which is responsible for converting androgens into estrogens. By reducing estrogen levels,
the body’s natural feedback mechanisms can be stimulated, leading to the release of an egg.
Elimination half life:
The elimination half-life of letrozole is approximately 2-3 days.
Route of Administration:
Letrozole is available in oral tablets. It is typically taken for a short period of time, usually around the time of ovulation.
Side effects:
Letrozole may cause some side effects, including:
- Hot flashes
- Night sweats
- Vaginal dryness
- Headaches
- Mood swings
- Joint pain
- Increased risk of multiple pregnancies
Dose:
The appropriate dose of letrozole will depend on your individual needs and medical history. Your healthcare provider will determine the best dose for you.
Precautions:
Before taking letrozole, it’s important to discuss any potential risks with your healthcare provider. Some precautions include:
- Ovarian hyperstimulation syndrome (OHSS): Letrozole can increase the risk of OHSS, a condition where the ovaries become overstimulated.
- Pregnancy: Letrozole should not be used during pregnancy.
- Liver problems: Letrozole should be used with caution in people with liver problems.
