Clomiphene Citrate: Stimulates ovulation.
Brief information about it:
Clomiphene citrate is a medication used to stimulate ovulation in women with infertility. It works by blocking the effects of estrogen, which can help stimulate the release of an egg from the ovary.
Uses:
· Infertility: Clomiphene citrate is often used as a first-line treatment for infertility caused by ovulation disorders.
· Polycystic ovary syndrome (PCOS): It can also be used to treat infertility in women with PCOS.
Mechanism of action:
Clomiphene citrate works by blocking the estrogen receptors in the hypothalamus and pituitary gland. This disrupts the normal feedback loop that regulates ovulation, causing the body to produce more follicle-stimulating hormone (FSH). Increased FSH levels can stimulate the growth and development of multiple follicles in the ovaries, increasing the chances of ovulation.
Elimination half life:
The elimination half-life of clomiphene citrate is approximately 5-7 days.
Route of Administration:
Clomiphene citrate is available in oral tablets. It is typically taken for a short period of time, usually around the time of ovulation.
Side effects:
Clomiphene citrate may cause some side effects, including:
- Hot flashes
- Night sweats
- Vaginal dryness
- Headaches
- Mood swings
- Joint pain
- Increased risk of multiple pregnancies
Dose:
The appropriate dose of clomiphene citrate will depend on your individual needs and medical history. Your healthcare provider will determine the best dose for you
Precautions:
Before taking clomiphene citrate, it’s important to discuss any potential risks with your healthcare provider. Some precautions include:
- Ovarian hyperstimulation syndrome (OHSS): Clomiphene citrate can increase the risk of OHSS, a condition where the ovaries become overstimulated.
- Pregnancy: Clomiphene citrate should not be used during pregnancy.
- Liver problems: Clomiphene citrate should be used with caution in people with liver problems.
